Mass Eye and Ear-led trial of procedure that took stem cells from a healthy eye and transplanted them into the damaged eye, safely restored corneal surfaces in 14 patients who were followed for 18 months An expanded clinical trial that tested a groundbreaking, experimental stem cell treatment for blinding cornea injuries found the treatment was […]

Key Takeaways CALEC treatment showed over 90% efficacy in restoring corneal surfaces in patients with previously untreatable cornea damage. The CALEC procedure involves expanding stem cells from a healthy eye and transplanting them into the damaged cornea. The trial demonstrated a high safety profile, with no serious adverse events reported in donor or recipient eyes. […]

A Mass Eye and Ear-led clinical trial of a procedure that took stem cells from a healthy eye and transplanted them into a damaged eye safely restored corneal surfaces in 14 patients who were followed for 18 months.The stem cell treatment for blinding cornea injuries — called cultivated autologous limbal epithelial cells, or CALEC — […]

The vitreous cavity was filled with perfluoro decalin to reattach the retina. Credit: Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, China, Yong Liu A study suggests that patients with wet AMD may regain vision through a novel approach — removing abnormal blood vessels and transplanting stem cell-derived retinal cells. Patients […]

Limbal Stem Cell Deficiency (LSCD) Repair A groundbreaking advancement in Japan offers hope for reversing blindness caused by eye damage through stem cell technology. At Osaka University Hospital, scientists have successfully restored vision in patients using induced pluripotent stem cells (iPSCs), derived from human blood. In a 2022 clinical trial, four individuals with limbal stem […]

Abstract Stem cell-based therapy has gained importance over the past decades due to huge advances in science and technology behind the generation and directed differentiation of pluripotent cells from embryos and adult cells. Preclinical proof-of-concept studies have been followed by clinical trials showing efficacy and safety of transplantation of stem cell-based therapy, which are beginning […]

Chapter Stem Cells for Therapy of Eye Diseases: Current Status Zala Lužnik Marzidovšek, Janina Simončič, Petra Schollmayer, Elvira Maličev, Primož Rožman and Marko Hawlina Abstract In recent years, the treatment of various ocular diseases using stem cells and stem cell-derived exosomes has rapidly evolved. In this chapter, we present the potential of different stem cells […]